Asociación entre la vitamina D, el control glicémico y las complicaciones microvasculares del Diabetes tipo I
DOI:
https://doi.org/10.5020/18061230.2018.6993Palabras clave:
Diabetes Mellitus, Vitamina D, Registros Médicos.Resumen
Objetivo: Evaluar la asociación entre los niveles de vitamina D, los parámetros del control metabólico y la presencia de complicaciones microvasculares de pacientes con Diabetes Mellitus Tipo I (DM1). Métodos: Estudio transversal, analítico y observacional realizado en 2016 en Fortaleza, Ceará, con historiales clínicos de cincuenta pacientes. Se investigaron los siguientes datos clínicos y epidemiológicos: el sexo, la edad, el IMC (Índice de Masa Corporal), el color de la piel, el control glicémico, la duración del diabetes, la dosis diaria de insulina, la presencia de complicaciones microvasculares y la dosificación de vitamina D por quimioluminiscencia. Se utilizaron las pruebas ecxato de Fisher, t-Student y Mann-Whitney con p< 0,05. Resultados: Se observó la deficiencia de vitamina D en 34 (68%) pacientes con media de 25(OH) de vitamina D, 23,24 ± 4,29 ng/mL en el grupo de vitamina D deficiente y 38,22± 7,72 ng/mL en el grupo de vitamina D suficiente. Además, 37 pacientes (78%) presentaron hemoglobina glicosilada por encima del 7% y semejante para los dos grupos. La dosis diaria de insulina en el grupo de vitamina D deficiente ha sido mayor que en el grupo de vitamina D suficiente, 54,81 + 27,4 vs 55,55 + 19,2, pero sin asociación significativa con los niveles de vitamina D. El nivel sérico de vitamina D no se ha asociado con los parámetros clínicos y epidemiológicos como el sexo, la edad, el IMC, el color de la piel, el control glicémico, la duración del diabetes, la dosis diaria de insulina y la presencia de complicaciones microvasculares. Conclusión: La deficiencia de vitamina D se dio en la mayoría de los pacientes con DM1 evaluados. Sin embargo, no hubo asociación entre la deficiencia y las variables clínicas y epidemiológicas analizadas.Descargas
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American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2017;40 (Suppl 1):S11-24
Milech A, Perez A, Golbert AA et al. Diretrizes da Sociedade Brasileira de Diabetes (2015-2016). São Paulo: A.C. Farmacêutica; 2016.
Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010;87(1):4-14.
Wolden-Kirk H, Overbergh L, Christesen HT, Brusgaard K, Mathieu C. Vitamin D and diabetes: its importance for beta cell and immune function. Mol Cell Endocrinol. 2011;347(1-2):106-20.
Atkinson MA, Eisenbarth GS, Michels AW. Type 1 diabetes. Lancet, 2014;383(9911):69-82.
Egro FM. Why is type 1 diabetes increasing? J Mol Endocrinol. 2013;51(1):R1-13.
Griz LH, Bandeira F, Gabbay MA, Dib SA, Carvalho EF. Vitamin D and diabetes mellitus: an update 2013. Arq Bras Endocrinol Metabol. 2014;58(1):1-8.
Gabbay MA, Sato MN, Finazzo C, Duarte AJ, Dib AS. Effect of cholecalciferol as adjunctive therapy with insulin on protective immunologic profile and decline of residual β-cell function in new-onset type 1 diabetes mellitus. Arch Pediatr Adolesc Med. 2012;166(7):601-7.
Mishra A, Dayal D, Sachdeva N, Attri SV. Effect of 6-months' vitamin D supplementation on residual beta cell function in children with type 1 diabetes: a case control interventional study. J Pediatr Endocrinol Metab. 2016;29(4):395-400.
Devaraj S, Jian I, Yun JM, Bremer. A demonstration of increased toll-like receptor 2 and toll-like receptor 4 expression in monocytes of type 1 diabetes mellitus patients with microvascular complications. Metabolism. 2011;60(2):256-9.
Kaur H, Donaghue KC, Chan AK, Benitez-Aguirre P, Hing S, Lloyd M, et al. Vitamin D deficiency is associated with retinopathy in children and adolescents with type 1 diabetes. Diabetes Care. 2011;34(6):1400-2.
Joergensen C, Hovind P, Schmedes A, Parving HH, Rossing P. Vitamin D levels, microvascular complications, and mortality in type 1 diabetes. Diabetes Care. 2011;34(5):1081-5.
Boer IH, Sachs MC, Cleary PA, Hoofnagle AN, Lachin JM, Molitch ME, et al. Diabetes control and complication trial/epidemiology of diabetes interventions and complications study research group: circulating vitamin d metabolites and kidney disease in type 1 diabetes. J Clin Endocrinol Metab. 2012;97(12):4780-8.
Shimo N, Yasuda T, Kaneto H, Katakami N, Kuroda A, Sakamoto F, et al. Vitamin D deficiency is significantly associated with retinopathy in young Japanese type 1 diabetic patients. Diabetes Res Clin Pract. 2014;106(2):e 41-3.
Alam U, Arul-Devah V, Javed S, Malik RA. vitamin d and diabetic complications: true or false prophet? Diabetes Ther. 2016;7(1):11-26.
Nwosu BU, Maranda L. The effects of vitamin D supplementation on hepatic dysfunction, vitamin D status, and glycemic control in children and adolescents with vitamin D deficiency and either type 1 or type 2 diabetes mellitus. PLoS One. 2014;9(6):e 99646.
World Health Organization. Obesity: preventing and managing the global epidemic. Report of a World Health Organization Consultation. Geneva: WHO; 2000. (WHO Obesity Technical Report Series, n. 284).
Cadenhead K. Council on health promotion: the vitamin D debate. BC Med J. 2015;57(9):414.
Muscogiuri G, Mitri J, Mathieu C, Badenhoop K, Tamer G, Orio F, et al. Mechanisms in endocrinology: vitamin D as a potential contributor in endocrine health and disease; Eur J Endocrinol. 2014;171(3):R101-10.
Mäkinen MV, Mykkänen J, Ilonen J, Veijola R, Hyöty H, Knip M, et al. An increase in serum 25-hydroxyvitamin d concentrations preceded a plateau in type 1 diabetes incidence in finnish children. J Clin Endocrinol Metab. 2014;99(11):e2353-6.
Svoren BM, Volkening LK, Wood JR, Laffel LM. Significant vitamin D deficiency in youth with type 1 diabetes mellitus. J Pediatr. 2009;154(1):132-4.
Savastio S, Cadario F, Genoni G, Bellomo G, Bagnati M, Secco G, et al. Vitamin D Deficiency and Glycemic Status in Children and Adolescents with Type 1 Diabetes Mellitus. PLoS One. 2016;11(9):e0162554.
Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Yakout SM, Aljohani NJ, et al. Lower vitamin D status is more common among Saudi adults with diabetes mellitus type 1 than in non-diabetics. BMC Public Health. 2014;14:153.
Daga RA, Laway BA, Shah ZA, Mir SA, Kotwal SK, Zargar AH. High prevalence of vitamin D deficiency among newly diagnosed youth-onset diabetes mellitus in north India. Arq Bras Endocrinol Metab. 2012;56(7):423-8.
Zipitis CS, Akobeng AK. Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Arch Dis Child. 2008;93(6):512-7.
Raab,J, Giannopoulou EZ, Schneider S, Warncke K, Krasmann M, Winkler C, et al. Prevalence of vitamin D deficiency in pre-type 1 diabetes and its association with disease progression. Diabetologia. 2014;57(5):902-8.
Miettinen ME, Reinert L, Kinnunen L, Harjutsalo V, Koskela P, Surcel HM, et al. Serum 25-hydroxyvitamin D level during early pregnancy and type 1 diabetes risk in the offspring. Diabetologia. 2012;55(5):1291-4.
Al Sawah S, Compher CW, Hanlon AL, Lipman TH. 25-Hydroxyvitamin D and glycemic control: a cross-sectional study of children and adolescents with type 1 diabetes. Diabetes Res Clin Pract. 2016;115:54-9.
Vitamin D supplement in early childhood and risk for type I (insulin-dependent) diabetes mellitus. The EURODIAB Substudy 2 Study Group. Diabetologia. 1999;42(1):51-4.
Treiber G, Prietl B, Fröhlich-Reiterer E, Lechner E, Ribitsch A, Fritsch M, et al. Cholecalciferol supplementation improves suppressive capacity of regulatory T-cells in young patients with new-onset type 1 diabetes mellitus: a randomized clinical trial. Clin Immunol. 2015;161(2):217-24.
Hossein-nezhad A, Holick MF. Vitamin D for health: a global perspective. Mayo Clinic Proc. 2013;88(7):720-55.
