Associação entre vitamina D, controle glicêmico e complicações microvasculares no diabetes tipo 1

Camila Lousada Herbster Ferraz; Angela Delmira Nunes Mendes; Tania Maria Bulcão Lousada Ferraz; Carlos Antonio Bruno da Silva

doi:10.5020/18061230.2018.6993

Autores/as

Camila Lousada Herbster Ferraz Universidade Federal do Ceara
Angela Delmira Nunes Mendes Ambulatório de Diabetes tipo 1 do Serviço de Endocrinologia e Metabologia do Hospital Universitário Walter Cantídio – UFC
Tania Maria Bulcão Lousada Ferraz Hospital Geral de Fortaleza
Carlos Antonio Bruno da Silva Universidade de Fortaleza http://orcid.org/0000-0002-2968-9206

DOI:

https://doi.org/10.5020/18061230.2018.6993

Palabras clave:

Diabetes Mellitus, Vitamina D, Registros Médicos.

Resumen

Objetivo: Evaluar la asociación entre los niveles de vitamina D, los parámetros del control metabólico y la presencia de complicaciones microvasculares de pacientes con Diabetes Mellitus Tipo I (DM1). Métodos: Estudio transversal, analítico y observacional realizado en 2016 en Fortaleza, Ceará, con historiales clínicos de cincuenta pacientes. Se investigaron los siguientes datos clínicos y epidemiológicos: el sexo, la edad, el IMC (Índice de Masa Corporal), el color de la piel, el control glicémico, la duración del diabetes, la dosis diaria de insulina, la presencia de complicaciones microvasculares y la dosificación de vitamina D por quimioluminiscencia. Se utilizaron las pruebas ecxato de Fisher, t-Student y Mann-Whitney con p< 0,05. Resultados: Se observó la deficiencia de vitamina D en 34 (68%) pacientes con media de 25(OH) de vitamina D, 23,24 ± 4,29 ng/mL en el grupo de vitamina D deficiente y 38,22± 7,72 ng/mL en el grupo de vitamina D suficiente. Además, 37 pacientes (78%) presentaron hemoglobina glicosilada por encima del 7% y semejante para los dos grupos. La dosis diaria de insulina en el grupo de vitamina D deficiente ha sido mayor que en el grupo de vitamina D suficiente, 54,81 + 27,4 vs 55,55 + 19,2, pero sin asociación significativa con los niveles de vitamina D. El nivel sérico de vitamina D no se ha asociado con los parámetros clínicos y epidemiológicos como el sexo, la edad, el IMC, el color de la piel, el control glicémico, la duración del diabetes, la dosis diaria de insulina y la presencia de complicaciones microvasculares. Conclusión: La deficiencia de vitamina D se dio en la mayoría de los pacientes con DM1 evaluados. Sin embargo, no hubo asociación entre la deficiencia y las variables clínicas y epidemiológicas analizadas.

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Biografía del autor/a

Camila Lousada Herbster Ferraz, Universidade Federal do Ceara

Residente de Endocrinologia e Metabologia do Hospital Universitário Walter Cantídio – UFC

Angela Delmira Nunes Mendes, Ambulatório de Diabetes tipo 1 do Serviço de Endocrinologia e Metabologia do Hospital Universitário Walter Cantídio – UFC

Medica Endocrinologista

Tania Maria Bulcão Lousada Ferraz, Hospital Geral de Fortaleza

Médica Endocrinologista, Doutora em Endocrinologia pela Escola Paulista de Medicina Fortaleza, UNIFESP São Paulo, Brasil

Carlos Antonio Bruno da Silva, Universidade de Fortaleza

Possui graduação em Medicina pela Universidade Federal do Ceará (1988), mestrado em Medicina (Clínica Médica) pela Universidade Federal do Ceará (1997) e doutorado em Ciências da Saúde pela Universidade de Brasília (2000). Atualmente é professor titular da Universidade de Fortaleza, médico do Governo do Estado do Ceará, - Parecerista do Jormal de Pediatria e dos Cadernos de Saúde Pública (FIOCRUZ) e gerente científico - Pronutrir -Suporte Nutricional e Quimioterapia Ltda. Tem experiência na área de Medicina, com ênfase em Endocrinologia, Nutrição e Educação em Saúde, atuando principalmente nos seguintes temas: nutrição, endocrinologia, diabetes mellitus e avaliação nutricional.

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