Association between vitamin D, glycemic control and microvascular complications in type 1 diabetes

Authors

  • Camila Lousada Herbster Ferraz Universidade Federal do Ceara
  • Angela Delmira Nunes Mendes Ambulatório de Diabetes tipo 1 do Serviço de Endocrinologia e Metabologia do Hospital Universitário Walter Cantídio – UFC
  • Tania Maria Bulcão Lousada Ferraz Hospital Geral de Fortaleza
  • Carlos Antonio Bruno da Silva Universidade de Fortaleza http://orcid.org/0000-0002-2968-9206

DOI:

https://doi.org/10.5020/18061230.2018.6993

Keywords:

Diabetes Mellitus, Vitamin D, Medical Records.

Abstract

Objectives: To assess the association between vitamin D levels, parameters of metabolic control and presence of microvascular complications in type 1 diabetes mellitus (T1DM) patients. Methods: Analytical and observational cross-sectional study of medical records of fifty patients carried out in 2016 in Fortaleza, Ceará. Clinical and epidemiological data were analyzed: sex, age, BMI (body mass index), skin color, glycemic control, duration of diabetes, daily insulin dose, presence of microvascular complications, and vitamin D assay by chemiluminescence. Fisher’s test, students’s t test and Mann-Whitney U test were used with p< 0.05. Results: Vitamin D deficiency was seen in 34 (68%) patients, with a mean of 25(OH) vitamin D of 23.24±4.29 ng/mL in the Vitamin D deficiency group and 38.22±7.72 ng/mL in the normal Vitamin D group. In addition, 37 patients (78%) exhibited glycated hemoglobin above 7%, which was similar in booth groups. The daily insulin dose in the vitamin D deficiency group was higher than in the normal vitamin D group, 54.81+27.4 vs 55.55+19.2, but with no significant association with vitamin D levels. Vitamin D levels were not associated with clinical and epidemiological such as: sex, age, BMI, skin color, glycemic control, duration of diabetes, daily insulin dose and presence of microvascular complications or insulin daily dose. Conclusion: Vitamin D deficiency was present in most of the T1DM patients analyzed. However, such deficiency was not associated with the clinical and epidemiological variables analyzed.

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Author Biographies

Camila Lousada Herbster Ferraz, Universidade Federal do Ceara

Residente de Endocrinologia e Metabologia do Hospital Universitário Walter Cantídio – UFC

Angela Delmira Nunes Mendes, Ambulatório de Diabetes tipo 1 do Serviço de Endocrinologia e Metabologia do Hospital Universitário Walter Cantídio – UFC

Medica Endocrinologista

Tania Maria Bulcão Lousada Ferraz, Hospital Geral de Fortaleza

Médica Endocrinologista, Doutora em Endocrinologia pela Escola Paulista de Medicina Fortaleza, UNIFESP São Paulo, Brasil

Carlos Antonio Bruno da Silva, Universidade de Fortaleza

Possui graduação em Medicina pela Universidade Federal do Ceará (1988), mestrado em Medicina (Clínica Médica) pela Universidade Federal do Ceará (1997) e doutorado em Ciências da Saúde pela Universidade de Brasília (2000). Atualmente é professor titular da Universidade de Fortaleza, médico do Governo do Estado do Ceará, - Parecerista do Jormal de Pediatria e dos Cadernos de Saúde Pública (FIOCRUZ) e gerente científico - Pronutrir -Suporte Nutricional e Quimioterapia Ltda. Tem experiência na área de Medicina, com ênfase em Endocrinologia, Nutrição e Educação em Saúde, atuando principalmente nos seguintes temas: nutrição, endocrinologia, diabetes mellitus e avaliação nutricional.

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Published

2018-06-21

How to Cite

Ferraz, C. L. H., Mendes, A. D. N., Ferraz, T. M. B. L., & Silva, C. A. B. da. (2018). Association between vitamin D, glycemic control and microvascular complications in type 1 diabetes. Brazilian Journal in Health Promotion, 31(2). https://doi.org/10.5020/18061230.2018.6993

Issue

Vol. 31 No. 2 (2018)

Section

Original Articles

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